"Run for your Ed" is the 19th episode of Season 4 and the 96th episode of Ed, Edd n Eddy. In this episode, the Kanker Sisters try to retrieve their missing ship in-a-bottle, even if it means embarking on a rampage; destroying the neighborhood in the process. In the meantime, the Eds find out that the ship in-a-bottle is stuck on Ed's finger and now they must try to find a way to get it off of Ed's finger.
One night at the Park n' Flush, the Kanker Sisters are fast asleep when they hear noises in their kitchen. The Kankers awaken from their sleep quickly and rush down the stairs, where they find that the thief that was there had gotten away, leaving the kitchen in a mess, and that is when they notice that their prized ship-'n'-a-bottle is missing. They realize the perpetrator had taken the bottle with him. Marie insists that they call the cops, but before May could remember the number to dial for 911, the phone is crushed by Lee, who would rather recover their ship-'n'-a-bottle "Kanker style".
The next day, Rolf is preparing to deliver a giant wiener to a market, when his animals start acting wildly. Rolf is quick to sense trouble approaching, and rushes all of his livestock to his cellar before it's too late.
Meanwhile, Edd and Eddy find out Ed had been sleep-walking again and that he was sleeping in Kevin's refrigerator when he stopped sleep-walking. Kevin has the other Eds come get their friend back while he starts on his chores, and when they do, they notice that Ed has a mysterious ship-'n'-a-bottle stuck on his finger. Edd determines that removing it will not be easy, and the trio try to find a way to get it off.
Meanwhile, the Kankers cause chaos throughout the entirety of Peach Creek, not just the Cul-de-Sac, leaving the kids cowering in fear. Soon comes the first debut of the "Kanker Hissy Fit", which causes more damage and destruction throughout the cul-de-sac and leaves everyone in peril.
Eddy first tries to pull it loose using trees for leverage, but they simply come crashing down on him. Without soap as an option for getting the ship-'n'-a-bottle off of Ed's finger (since Ed is scared of it), Ed suggests they use sticky tape. So, they go to Sarah's bedroom to find the tape without her permission, where Sarah is hiding away in her toy box from the Kankers. She scolds the Eds for entering her room without her seeking permission first, and the Eds leave for Edd's house with the tape. Shortly after, the Kankers show up to destroy Sarah's room while searching for their lost possession. Sarah thinks that it's the Eds again. She pops out of her toy box and screams at her brother, only to get spotted by the Kankers and be tied up in a sack by them and have her mouth shut (literally). When Sarah learns that the Kankers are looking for a ship-'n'-a-bottle, she remembers seeing Ed with one stuck to his finger. She manages to unseal her mouth and blurts to the Kankers about her sightings on their ship in a bottle.
Meanwhile, the Eds fail to get the ship-'n'-a-bottle off of Ed's finger through the tape; taping the bottle to the ceiling and jumping off the banister simply rips off a piece of the ceiling. While trying to twist the bottle off, the Kankers stop at Edd's house. Edd realizes that the bottle is theirs and calmly closes the door and locks it before he immediately freaks out and tells the others who the bottle belongs to, causing Eddy and Ed to freak out. After the Kankers break down the door, the Eds try to hide from the Kankers, but they fail to stay hidden in the cupboard under the kitchen sink.
The sisters extract them through the faucet, and Eddy is quick to brace for a heavy hitting. However, the Kankers just take the bottle off of Ed's finger since that is what they came for this whole time. The girls then leave with their possession, arguing over who gets to carry it while they head back home. The Eds make it out safely except for Eddy, who somehow got his finger stuck in the faucet. Edd leaves to get soap for the problem while Ed leaves to get the Kankers to help with it, much to Eddy's fear. Rolf, meanwhile, stays hidden in his cellar through the end of the episode, and the Cul-de-Sac has been almost completely destroyed due to the Kankers' rampage.
When Lee tells her sisters they should get the bottle back "Kanker style", Marie's wristband disappears.
When the Kankers enter Kevin's yard, Marie is wearing her normal clothes. When the camera pans behind her, Marie is still wearing her pajamas.
When the camera overviews the Cul-de-Sac, Ed and Sarah's House is destroyed. In the next scene, Sarah is shown hiding in her room, with the house completely unaffected.
When Edd answers the door and sees the Kankers, only a basic lock can be seen on it. Moments later, Edd closes the door and secures it with a door chain.
When the camera focuses on Edd while under the sink, Ed's foot is the color of Eddy's skin.
This is the second time Ed's sleepwalking and sleep eating problems are shown. The first time was in "A Glass of Warm Ed."
Ed appears to be terrified of soap in this episode, as was previously shown in "Once Upon an Ed."
A bottle can be seen in the wave on the title card, referring to the Kanker's ship-in-a-bottle and the plot of the episode.